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These interactions may underpin its potential influence on neurotransmission, neural excitability, and stress adaptation

Interest comes from their influence on hormones, ovulation, or immune balance, but there is scant clinical evidence for fertility enhancement

TLR4 can enhance the production of pro-inflammatory cytokines and chemokines, such as IL-6 and IL-17, by binding with exogenous ligands, like peptidoglycan, in FLS and peripheral blood mononuclear (PBMC) from RA patients, and trigger cartilage inflammation and degeneration (135)